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什么是多基因风险评分 2023-07-27 多基因风险评分(polygenic risk score,PRS)是一种利用遗传变异信息预测个体患病风险的方法。PRS是基于大规模的遗传关联研究(genome-wide association study,GWAS),通过统计学方法将多个与某种疾病相关的遗传变异(如单核苷酸多态性,SNP)组合成一个单一的数值,反映个体的遗传易感性。PRS可以应用于多种复杂疾病的风险评估,如心血管疾病、癌症、精神疾病等,为个体化医疗提供参考。 PRS的计算方法有多种,但基本思路是将每个遗传变异的效应大小(如风险比例或回归系数)乘以个体在该位点的基因型(0、1或2),然后将所有位点的结果相加得到PRS。不同的方法主要在于如何选择遗传变异和权重效应大小。一般来说,选择更多的遗传变异可以提高PRS的解释力,但也会增加噪音和过拟合的风险。因此,需要根据不同的目的和数据特点,选择合适的方法和参数。 PRS的应用前景广阔,但也存在一些挑战和局限性。例如,PRS的准确性受到样本量、群体结构、环境因素等多方面的影响,需要进行适当的校正和验证。此外,PRS的临床意义和伦理问题也需要进一步探讨和规范。总之,PRS是一种有价值的遗传风险评分方法,但也需要谨慎和科学地使用。

科学原理 The Science of Polygenic Scoring

416   2025-02-09

Clinical Application of PRS

Polygenic Risk Scores (PRS) can be applied to clinical prediction, though there are both advantages and limitations to t...
437   2025-02-09

What is PRS?

A Polygenic Risk Score (PRS) is a numerical value that represents an individual's genetic predisposition to a certain tr...
Your genetics play a significant role in determining your predisposition to various health conditions. Certain genetic v...
Polygenic risk scores (PRS) are a revolutionary technological advancement in the field of genetics, offering significant...
3903   2023-07-27

什么是多基因风险评分

多基因风险评分(polygenic risk score,PRS)是一种利用遗传变异信息预测个体患病风险的方法。PRS是基于大规模的遗传关联研究(genome-wide association study,GWAS),通过统计学方法将多个与...
公司简介

Gene to Health Limited primarily focuses on developing multi-omics predictive models for common disease risks, conducting biomedical big data analysis and modeling, and providing bioinformatics research services.  We are a pioneer in Asia focused on polygenic scoring technology, leveraging millions of disease-related genetic variants and other omics data to predict over 1000 traits and diseases. Our core product suite, G2H, provides personalized health management solutions in one platform, including risk assessments for chronic diseases, dietary optimization, lifestyle advisory, and cancer risk prediction. We aim to revolutionize disease prevention and improve early disease intervention by integrating advanced genomic analysis, ML and AI.

我们是来自香港大学医学院 (HKU Med) 的博士创业团队,拥有以Polygenic Scoring (多基因风险评分,PGS)的核心技术,基因智健(G2H)平台是我们开发的核心产品。该平台主要利用基于多组学大数据的统计机器学习模型分析用户数据,从而预测和评估上千种种人类疾病风险和健康表型,为您的健康人生保驾护航。

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聯繫人: Dr. CHEN Guolan Lane
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